ea0038p307 | Pituitary | SFEBES2015
Mothojakan Nadira B
, Stiles Craig E
, Barry Sayka
, Shoulders Carol C
, Korbonits Marta
: AIP mutation-positive familial isolated pituitary adenoma is commonly diagnosed in young patients who have a poor prognosis due to large, treatment-resistant tumours. Microarray analysis carried out on AIP knockdown pituitary (GH3) cells and control cells, identified CDC42 as one of the genes that was up-regulated by loss of AIP protein. This small Rho GTPase activates MAPK signalling, suggesting it may contribute to the proliferative phenotype of AIP knock...